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ALX-550-002 Revised 07-Oct-08
LY-83,583
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SYNONYMS 6-(Phenylamino)-5,8-quinolinedione
6-Anilino-5,8-quinolinedione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-002-M005   5 mg 55.00 USD Add To Cart
ALX-550-002-M025   25 mg 220.00 USD Add To Cart
ALX-550-002-M100   100 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C15H10N2O2
MW: 250.3
CAS NUMBER: 91300-60-6
SOURCE/HOST: Synthetic.
PURITY: ≥95%
APPEARANCE: Dark red powder.
SOLUBILITY: Soluble in methanol or diluted aqueous acid. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: NEUROTOXIN.

Product Description
Competitive inhibitor of soluble guanylyl cyclase (sGC) (IC50=2µM) and of cGMP production.
Product Specific Literature References
Pharmacologic analysis of two novel inhibitors of leukotriene (slow reacting substance) release: J.H. Fleisch, et al.; J. Pharmacol. Exp. Ther. 229, 681 (1984) Abstract
LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase: A. Mülsch, et al.; J. Pharmacol. Exp. Ther. 247, 283 (1988) Abstract
Interleukin 1 induces prolonged L-arginine-dependent cyclic guanosine monophosphate and nitrite production in rat vascular smooth muscle cells: D. Beasley, et al.; J. Clin. Invest. 87, 602 (1991) Abstract
Modification by LY 83583 and methylene blue of relaxation induced by nitric oxide, glyceryl trinitrate, sodium nitroprusside and atriopeptin in aortae of the rat, guinea-pig and rabbit: T. Kawada, et al.; Gen. Pharmacol. 25, 1361 (1994) Abstract
A comparative study of the effects of three guanylyl cyclase inhibitors on the L-type Ca2+ and muscarinic K+ currents in frog cardiac myocytes: N. Abi-Gerges, et al.; Br. J. Pharmacol. 121, 1369 (1997) Abstract
Guanylyl cyclase inhibition reduces contractility and decreases cGMP and cAMP in isolated rat hearts: R.E. Klabunde, et al.; Cardiovasc. Res. 37, 676 (1998) Abstract
Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation: T.H. Murphy, et al.; J. Neurochem. 70, 2156 (1998) Abstract
Inhibition of nitric oxide formation and superoxide generation during reduction of LY83583 by neuronal nitric oxide synthase: Y. Kumagai, et al.; Eur. J. Pharmacol. 360, 213 (1998) Abstract
Nitric oxide stimulates cGMP production and mimics synaptic responses in metacerebral neurons of Aplysia: H.Y. Koh and J.W. Jacklet; J. Neurosci. 19, 3818 (1999) Abstract; Full Text
LY-83583 stimulates glucose transporter-1-mediated glucose transport independent of changes in cGMP levels: R.K. Prasad, et al.; Eur. J. Pharmacol. 366, 101 (1999) Abstract
The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats
:
A.C. Ribeiro & L. Kapas; Brain Res. 1049, 25 (2005) Abstract
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
 
 

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