ALEXIS Biochemicals: LY2183240

ALX-550-411

Revised 11-Apr-07

LY2183240
SYNONYMS	5-Biphenyl-4-ylmethyltetrazole-1-carboxylic acid dimethylamide
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Anandamide Uptake Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-411-M010		10 mg	60.00 USD
ALX-550-411-M050		50 mg	240.00 USD

Product Specification

FORMULA:	C₁₇H₁₇N₅O
MW:	307.4
CAS NUMBER:	874902-19-9
PURITY:	≥98% (TLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO or dimethyl formamide.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Initially described as potent, competitive small molecule inhibitor of anandamide uptake. Has recently been shown to inhibit fatty acid amide hydrolase (FAAH) and several additional serine hydrolases.

Product Specific Literature References

Identification of a high-affinity binding site involved in the transport of endocannabinoids: S.A. Moore, et al.; PNAS 102, 17852 (2005) Abstract; Full Text
Toward an anandamide transporter: R. Mechoulam and D.G. Deutsch; PNAS 102, 17541 (2005) Abstract
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases: J.P. Alexander and B.F. Cravatt; JACS 128, 9699 (2006) Abstract
Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors: A.K. Dickason-Chesterfield, et al.; Cell. Mol. Neurobiol. 26, 407 (2006) Abstract

Further Categories Containing This Product:

Fatty Acid Amide Hydrolase [FAAH] / Related Products

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