ALEXIS Biochemicals: Latrunculin B

ALX-350-036

Revised 18-Jan-08

Latrunculin B
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Cytoskeletal Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-036-C100		100 µg	48.00 USD
ALX-350-036-M001		1 mg	120.00 USD

Product Specification

FORMULA:	C₂₀H₂₉NO₅S
MW:	395.5
CAS NUMBER:	76343-94-7
MERCK INDEX:	14: 5378
SOURCE/HOST:	Isolated from Latrunculia magnifica.
PURITY:	≥97% (HPLC)
APPEARANCE:	White to light yellow solid.
SOLUBILITY:	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Structurally unique marine toxin. Actin filament modulator. 10- to 100-fold more potent than cytochalasins. Whereas cytochalasin D (Prod. No. ALX-380-031) induces dissolution of F-actin and stress fiber contraction in fibroblasts in culture, latrunculin B causes a shortening and thickening of stress fibers.

Product Specific Literature References

Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219, 493 (1983) Abstract
Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell. Res. 166, 191 (1986) Abstract
Inhibition of actin polymerization by latrunculin: M. Coue, et al.; FEBS Lett. 213, 316 (1987) Abstract
Latrunculin A is a potent inhibitor of phagocytosis by macrophages: C.A. de Oliveira & B. Mantovani; Life Sci. 43, 1825 (1988) Abstract
Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motility & Cytoskeleton 13, 127 (1989) Abstract
Effects of cytochalasin D and latrunculin B on mechanical properties of cells: T. Wakatsuki, et al.; J. Cell. Sci. 114, 1025 (2001) Abstract

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