ALEXIS Biochemicals: Leptin (mouse) (recombinant)

ALX-201-035

Revised 18-May-06

Leptin (mouse) (recombinant)
SYNONYMS	OB Gene Product (mouse) (recombinant)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Leptin/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-035-M001		1 mg	190.00 USD

Product Specification

MW:	~16kDa.
MERCK INDEX:	14: 5443
SOURCE/HOST:	Produced in E. coli. Homologous to mouse serum leptin.
PURITY:	≥98% (SDS-PAGE)
FORMULATION:	Lyophilized from 0.0045mM sodium bicarbonate.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein.
RECONSTITUTION:	Reconstitute with sterile water or 0.4% sodium bicarbonate, pH 8-9. Do not reconstitute to less than 0.1mg/ml. Further dilutions should be made with medium containing a carrier protein.
BIOLOGICAL ACTIVITY:	Induces proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Reconstituted protein is stable for 4 weeks when stored at +4°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Information

Leptin, the product of the ob (obese) gene, is a 16kDa protein consisting of 146 amino acid residues. Leptin is produced in the adipose tissue, and is considered to play an important role in appetite control, fat metabolism and regulation of body weight. Studies have shown that it may also influence reproductive function. Mice with ob/ob genotype develop a form of diabetes similar to type II in humans.

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link 41160: Leptin (mouse) (precursor)
AfCS Signalling Gateway link A001397: Leptin (mouse)

General Literature References

Positional cloning of the mouse obese gene and its human homologue: Y. Zhang, et al.; Nature 372, 425 (1994) Abstract
Effects of the obese gene product on body weight regulation in ob/ob mice: M.A. Pelleymounter, et al.; Science 269, 540 (1995) Abstract
Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects: M. Maffei, et al.; Nature Med. 1, 1155 (1995) Abstract
Weight-reducing effects of the plasma protein encoded by the obese gene: J.L. Halaas, et al.; Science 269, 543 (1995) Abstract

Further Categories Containing This Product:

Recombinant Proteins/Fusion Proteins

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