ALEXIS Biochemicals: Leptomycin A

ALX-380-101

Revised 12-Oct-07

Leptomycin A
SYNONYMS	ATS1287 A LMA
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Antifungal

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-101-C050		50 µg	75.00 USD
ALX-380-101-C100		100 µg	120.00 USD

Product Specification

FORMULA:	C₃₂H₄₆O₆
MW:	526.7
CAS NUMBER:	87081-36-5
SOURCE/HOST:	Isolated from Streptomyces sp.
CONCENTRATION:	0.1mg/ml
PURITY:	≥95% (HPLC)
APPEARANCE:	Liquid. In 100% ethanol.
SOLUBILITY:	Soluble in methanol or 100% ethanol.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Packaged under inert gas.
HAZARD:	FLAMMABLE. TOXIC.

Product Description

Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA.

Product Specific Literature References

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization: T. Hamamoto, et al.; J Antibiot (Tokyo) 36, 639 (1983) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Please also see our Product Flyer "LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport".

Further Categories Containing This Product:

Antibiotics for Cell Cycle Research • Nuclear Envelope & Nuclear Transport

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