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ALX-380-276 Revised 14-Feb-08
Lincomycin . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-276-UM01   1 MU 40.00 USD Add To Cart
Product Specification
FORMULA: C18H34N2O6S . HCl
MW: 406.6 . 36.5
CAS NUMBER: 7179-49-9
MERCK INDEX: 14: 5500
RTECS: RH6315000
SOURCE/HOST: Isolated from Streptomyces lincolnensis.
PURITY: ≥82% (on dry basis)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in water (50mg/ml).
ACTIVITY: Potency is 800-900µg/ml.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Lincosamide antibiotic. Forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Effective against Gram-positive bacteria.
Product Specific Literature References
Animal toxicity studies of a new antibiotic, lincomycin: J.E. Gray, et al.; Toxicol. Appl. Pharmacol. 6, 476 (1964) Abstract
Microbial kinetics of drug action against gram-positive and gram-negative organisms. III: Effect of lincomycin and clindamycin combinations on Staphylococcus aureus and Escherichia coli: S.M. Heman-Ackah; J. Pharm. Sci. 64, 1621 (1975) Abstract
Slow-onset inhibition of ribosomal peptidyltransferase by lincomycin: S. Kallia-Raftopoulos, et al.; Arch. Biochem. Biophys. 298, 332 (1992) Abstract
Peptidyl transferase antibiotics perturb the relative positioning of the 3’-terminal adenosine of P/P’-site-bound tRNA and 23S rRNA in the ribosome: S.V. Kirillov, et al.; RNA 5, 1003 (1999) Abstract; Full Text
Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibiotics: W.S. Champney & C.L. Tober; Curr. Microbiol. 41, 126 (2000) Abstract
Lincomycin protects mice from septic shock in beta-glucan-indomethacin model: S. Nameda, et al.; Biol. Pharm. Bull. 30, 2312 (2007) Abstract; Full Text
 
 
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