ALEXIS Biochemicals: Lipid A from Salmonella minnesota R595 (Re) (TLRgrade™) (Ready-to-Use)

ALX-581-201

Revised 16-Sep-08

Lipid A from Salmonella minnesota R595 (Re) (TLRgrade™) (Ready-to-Use)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Lipopolysaccharides [LPS] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-581-201-L002		2 ml	320.00 USD

Product Specification

SOURCE/HOST:	Isolated from Salmonella minnesota R595 (Re mutant). Prepared by mild acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method [1,2]), converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION:	1mg/ml
PURITY:	≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
FORMULATION:	Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY:	Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Keep sterile.
HAZARD:	HIGHLY PYROGENIC. HARMFUL.

Product Specific Literature References

[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Methods in Carbohydrate Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
[4] CD14 is required for MyD88-independent LPS signaling: Z. Jiang, et al.; Nat. Immunol. 6, 565 (2005) Abstract
[5] IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages: N. Schuetze, et al.; Int. Immunol. 17, 649 (2005) Abstract

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