ALEXIS Biochemicals: Loxoribine

ALX-480-097

Revised 02-Mar-07

Loxoribine
SYNONYMS	7-Allyl-8-oxoguanosine RWJ 21757
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	TLR Agonists Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-097-M025		25 mg	120.00 USD
ALX-480-097-M100		100 mg	360.00 USD

Product Specification

FORMULA:	C₁₃H₁₇N₅O₆
MW:	339.3
CAS NUMBER:	121288-39-9
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO (30mg/ml), water (10mg/ml), water:acetonitrile (1:1) (20mg/ml) or water:methanol (1:1) (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Selective ligand for Toll-like receptor 7 (TLR7) via IFN. Activates natural killer cells and primes cytolytic precursor cells for activation by IL-2.

Product Specific Literature References

Loxoribine (7-allyl-8-oxoguanosine) activates natural killer cells and primes cytolytic precursor cells for activation by IL-2: B.L. Pope, et al.; J. Immunol. 151, 3007 (1993) Abstract
Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle: M.G. Goodman, et al.; Blood 84, 3457 (1994) Abstract; Full Text
Three NF-kappa B binding sites in the human E-selectin gene required for maximal tumor necrosis factor alpha-induced expression: U. Schindler and V.R. Baichwal; Mol. Cell. Biol. 14, 5820 (1994) Abstract; Full Text
The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines: B.L. Pope, et al.; Cell. Immunol. 162, 333 (1995) Abstract
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7: J. Lee, et al.; PNAS 100, 6646 (2003) Abstract; Full Text
Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN: I.B. Bekeredjian-Ding, et al.; J. Immunol. 174, 4043 (2005) Abstract; Full Text

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