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ALX-350-038 Revised 07-Apr-08
Luffariellolide
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-038-M001   1 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C25H38O3
MW: 386.6
CAS NUMBER: 111149-87-2
SOURCE/HOST: Isolated from sponge Luffariella sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Structurally related to manoalide (Prod. No. ALX-350-045). Anti-inflammatory phospholipase A2 (PLA2) inhibitor (IC50=0.23µM). Less potent than manoalide, but partially reversible. Inhibits human recombinant sPLA2 selectively over cPLA2.
Product Specific Literature References
Luffariellolide, an anti-inflammatory sesterterpene from the marine sponge Luffariella spp.: K.F. Albizati, et al.; Experientia 43, 949 (1987)
PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase: K.B. Glaser, et al.; Agents Actions 34, 89 (1991) Abstract
Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis: L.A. Marshall, et al.; Agents Actions 37, 60 (1992) Abstract
Further Categories Containing This Product:
PLA2 Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
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