ALEXIS Biochemicals: MAHMA NONOate

ALX-430-015

Revised 18-Feb-08

MAHMA NONOate
SYNONYMS	NOC-9 MAHMA/NO (Z)-1-(N-Methyl-N-[6-(N-methylammoniohexyl)amino])-diazen-1-ium-1,2-diolate
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-015-M005		5 mg	30.00 USD
ALX-430-015-M025		25 mg	100.00 USD
ALX-430-015-5005		5x5 mg	120.00 USD

Product Specification

FORMULA:	C₈H₂₀N₄O₂
MW:	204.3
CAS NUMBER:	146724-86-9
PURITY:	≥97% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Relatively stable in alkaline solution.
HANDLING:	Protect from light and moisture.
HAZARD:	IRRITANT.

Product Description

Nitric oxide (NO) donor. The half-life time of MAHMA NONOate is 2.7 min. at 22°C in 0.1M phosphate buffer, pH 7.4. Decomposition of NONOates is nearly instantaneous at pH 5.0.

Product Specific Literature References

New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate: K.L. Homer & J.C. Wanstall; Br. J. Pharmacol. 137, 1071 (2002) Abstract
Platelet inhibitory effects of the nitric oxide donor drug MAHMA NONOate in vivo in rats: K.L. Homer & J.C. Wanstall; Eur. J. Pharmacol. 482, 265 (2003) Abstract
Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT): L.J. Bryan-Lluka, et al.; Br. J. Pharmacol. 143, 63 (2004) Abstract

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