ALEXIS Biochemicals: MAZ51

ALX-270-342

Revised 06-Dec-04

MAZ51
SYNONYMS	3-(4-Dimethylamino-naphthalen-1-yl-methylene)-1,3-dihydro-indol-2-one
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	VEGFs & VEGF-Rs Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-342-M002		2 mg	90.00 USD

Product Specification

FORMULA:	C₂₁H₁₈N₂O
MW:	314.4
CAS NUMBER:	163655-37-6
PURITY:	≥98%
APPEARANCE:	Orange crystals.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Keep under inert gas. Protect from light.
HAZARD:	TOXIC.

Product Description

Inhibits vascular endothelial cell growth factor-C (VEGF-C)-induced intracellular phosphorylation of VEGFR-3 (Flt-4) (IC₅₀=1µM).

Product Specific Literature References

Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2: V. Kirkin, et al.; Eur. J. Biochem. 268, 5530 (2001) Abstract

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Tyrosine Kinase Inhibitors

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