ALEXIS Biochemicals: MDL-27,032

ALX-270-081

Revised 20-Dec-02

MDL-27,032
SYNONYMS	4-Propyl-5-(4-pyridinyl)-2(3H)-oxazolone
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PKC Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-081-C100		100 µg	50.00 USD
ALX-270-081-M001		1 mg	200.00 USD

Product Specification

FORMULA:	C₁₁H₁₂N₂O₂
MW:	204.2
PURITY:	≥97%
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent vasodilator. Inhibitor of protein kinase C and cAMP-dependent protein kinase (PKA). Inhibition is competitive with ATP and not competitive with phospholipid, diacylglycerol, phorbol ester and calcium.

Product Specific Literature References

MDL 27,032 [4-propyl-5-(4-pyridinyl)-2(3H)-oxazolone], an active site- directed inhibitor of protein kinase C and cyclic AMP-dependent protein kinase that relaxes vascular smooth muscle: P.J. Robinson, et al.; J. Pharmacol. Exp. Ther. 255, 1392 (1990) Abstract

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