ALEXIS Biochemicals: MEG . sodium succinate

ALX-270-252

Revised 03-Mar-05

MEG . sodium succinate
SYNONYMS	Mercaptoethylguanidine . sodium succinate
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	NOS Inhibitors (NOS Induction & Enzyme Activity)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-252-M010		10 mg	95.00 USD

Product Specification

FORMULA:	C₃H₁₀N₃S . C₄H₄O₄Na
MW:	120.2 . 139.1
PURITY:	≥90%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Keep under inert gas. Keep cool and dry. Protect from moisture.

Product Description

Inhibitor of inducible nitric oxide synthase (iNOS; NOS II). Peroxynitrite scavenger.

Product Specific Literature References

Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform: G.J. Southan, et al.; Br. J. Pharmacol. 117, 619 (1996) Abstract
The inhibitory effects of mercaptoalkylguanidines on cyclo-oxygenase activity: B. Zingarelli, et al.; Br. J. Pharmacol. 120, 357 (1997) Abstract
Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage: C. Szabó, et al.; J. Biol. Chem. 272, 9030 (1997) Abstract; Full Text
Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation: S. Cuzzocrea, et al.; Free Radic. Biol. Med. 24, 450 (1998) Abstract
Protective effects of MEG, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat [published erratum appears in Br. J. Pharmacol. 123, 741 (1998)]: Z. Lohinai, et al.; Br. J. Pharmacol. 123, 353 (1998) Abstract
Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats: B. Zingarelli, et al.; J. Pharmacol. Exp. Ther. 287, 1048 (1998) Abstract
Modulation of peroxynitrite- and hypochlorous acid-induced inactivation of alpha1-antiproteinase by mercaptoethylguanidine: M. Whiteman, et al.; Br. J. Pharmacol. 126, 1646 (1999) Abstract

Further Categories Containing This Product:

Peroxynitrite / Scavengers / Detection

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