ALEXIS Biochemicals: MG-132

ALX-260-092

Revised 05-Jun-08

MG-132
SYNONYMS	Z-LLL-CHO Z-Leu-Leu-Leu-CHO
PRODUCT LINE	Ubiquitin & Proteasome
PRODUCT CATEGORY	Proteasome / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-092-M001		1 mg	25.00 USD
ALX-260-092-M005		5 mg	60.00 USD

Product Specification

SEQUENCE:	Z-Leu-Leu-Leu-CHO
FORMULA:	C₂₆H₄₁N₃O₅
MW:	475.6
CAS NUMBER:	133407-82-6
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by MS.

Product Description

Potent, reversible and cell permeable proteasome inhibitor. Inhibits NF-κB activation.

Product Specific Literature References

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules: K.L. Rock, et al.; Cell 78, 761 (1994) Abstract
Multiple proteolytic systems, including the proteasome, contribute to CFTR processing: T.J. Jensen, et al.; Cell 83, 129 (1995) Abstract
The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression: M.A. Read, et al.; Immunity 2, 493 (1995) Abstract
Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae: D.H. Lee and A.L. Goldberg; J. Biol. Chem. 271, 27280 (1996) Abstract; Full Text
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol: E.J. Wiertz, et al.; Cell 84, 769 (1996) Abstract
Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis: A.B. Meriin, et al.; J. Biol. Chem. 273, 6373 (1998) Abstract; Full Text
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIalpha expression: L. Salmena, et al.; Biochem. Pharmacol. 61, 795 (2001) Abstract

Further Categories Containing This Product:

NF-kB Pathway Inhibitors

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