ALEXIS Biochemicals: MJ33

ALX-300-145

Revised 18-Dec-07

MJ33
SYNONYMS	1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol . Li
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phospholipids / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-145-M005		5 mg	95.00 USD

Product Specification

FORMULA:	C₂₂H₄₃F₃O₆P . Li
MW:	491.6 . 6.9
PURITY:	≥93%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.

Product Description

Active site-directed, specific, competitive, and reversible inhibitor of phospholipase A₂ (PLA₂). Shows high specificity for type I (pancreatic) and bee venom PLA₂, but has relatively poor affinity for type II human synovial PLA₂.

Product Specific Literature References

Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition state analogues: M.K. Jain, et al.; Biochemistry 30, 10256 (1991) Abstract
A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung: A.B. Fisher, et al.; Biochem. J. 288, 407 (1992) Abstract
Inhibition of lung calcium-independent phospholipase A2 by surfactant protein A: A.B. Fisher, et al.; Am. J. Physiol. 267, L335 (1994) Abstract
Purification and characterization of a calcium-independent acidic acid phospholipase A2 from rat lung: R. Wang, et al.; Biochem. J. 304, 131 (1994) Abstract
Role of acidic Ca2+-independent phospholipase A2 in synthesis of lung dipalmitoyl phosphatidylcholine: A.B. Fisher, et al.; Am. J. Physiol. 272, L238 (1997) Abstract
Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein: T.S. Kim, et al.; J. Biol. Chem. 272, 2542 (1997) Abstract; Full Text
Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol: K. Sekar, et al.; Biochemistry 36, 14186 (1997) Abstract
Cloning and expression of rat lung acidic Ca2+-independent PLA2 and its organ distribution: T.S. Kim, et al.; Am. J. Physiol. 274, L750 (1998) Abstract
Role of phospholipase A2 (group I secreted) in the genesis of basal tone in the internal anal sphincter smooth muscle: M.A. de Godoy & S. Rattan; Am. J. Physiol. Gastrointest. Liver. Physiol. 293, G979 (2007) Abstract

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