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ALX-340-021 Revised 04-Jun-08
MK-571 . sodium salt
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-340-021-M005   5 mg 45.00 USD Add To Cart
ALX-340-021-M025   25 mg 190.00 USD Add To Cart
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Product Specification
FORMULA: C26H26ClN2O3S2 . Na
MW: 514.1 . 23.0
CAS NUMBER: 115104-28-4
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Aqueous stock solutions may be stable for more than 24 hours but we recommend making a fresh preparation before use.
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Leukotriene LTD4 receptor antagonist that potently inhibits MRP1.
Product Specific Literature References
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance: V. Gekeler, et al.; BBRC 208, 345 (1995) Abstract
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide: L. Vernhet, et al.; Biochem. Pharmacol. 61, 1387 (2001) Abstract
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic: J. Liu, et al.; Mol. Pharmacol. 60, 302 (2001) Abstract
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?: K. Jones, et al.; Aids 15, 1353 (2001) Abstract
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells: U. Stein, et al.; Int. J. Cancer 97, 751 (2002) Abstract
Further Categories Containing This Product:
MDR Inhibitors
 
 
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