ALEXIS Biochemicals: MK-886

ALX-270-368

Revised 08-Dec-04

MK-886
SYNONYMS	L-663,536 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid, Na
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Antagonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-368-M005		5 mg	60.00 USD
ALX-270-368-M025		25 mg	225.00 USD

Product Specification

FORMULA:	C₂₇H₃₃ClNO₂S . Na
MW:	471.1 . 23.0
CAS NUMBER:	118414-82-7
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	We do not recommend storing solutions for more than one day.

Product Description

Inhibitor of PPARα activation. Inhibits 5-lipoxygenase activating protein (FLAP) and leukotriene biosynthesis (IC₅₀=102nM). Induces apoptosis through the mitochondrial pathway.

Product Specific Literature References

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor: J. Gillard, et al.; Can. J. Physiol. Pharmacol. 67, 456 (1989) Abstract
Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886: J.P. Kehrer, et al.; Biochem. J. 356, 899 (2001) Abstract; Full Text
Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors: A. Gugliucci, et al.; J. Biol. Chem. 277, 31789 (2002) Abstract; Full Text

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