ALEXIS Biochemicals: ML-9 . hydrochloride

ALX-270-084

Revised 28-Jan-05

ML-9 . hydrochloride
SYNONYMS	1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Myelin Basic Protein / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-084-M010		10 mg	65.00 USD
ALX-270-084-M025		25 mg	125.00 USD

Product Specification

FORMULA:	C₁₅H₁₇ClN₂O₂S . HCl
MW:	324.8 . 36.5
CAS NUMBER:	105637-50-1
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in water or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Inhibitor of myosin light chain kinase, protein kinase C (PKC) and protein cAMP-dependent protein kinase (PKA). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

Product Specific Literature References

The modulatory role of myosin light chain phosphorylation in human platelet activation [published erratum appears in Biochem Biophys Res Commun 1987 Jan 15;142(1):287]: M. Saitoh, et al.; BBRC 140, 280 (1986) Abstract
Effects of myosin light-chain kinase inhibitor on catecholamine secretion from rat pheochromocytoma PC12h cells: T. Nagatsu, et al.; BBRC 143, 1045 (1987) Abstract
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase: M. Saitoh, et al.; J. Biol. Chem. 262, 7796 (1987) Abstract; Full Text
Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle: M. Seto, et al.; Eur. J. Pharmacol. 195, 267 (1991) Abstract
Naphthalenesulfonamide derivatives ML9 and W7 inhibit catecholamine secretion in intact and permeabilized chromaffin cells: J.A. Reig, et al.; Neurochem. Res. 18, 317 (1993) Abstract

Further Categories Containing This Product:

PKC Inhibitors • PKA Inhibitors • Myosin Light Chain Kinase Inhibitors

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