ALEXIS Biochemicals: Magnolol

ALX-350-352

Revised 06-Mar-08

Magnolol
SYNONYMS	5,5’-Diallyl-2,2’-biphenyldiol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Angiogenesis Research

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-352-M005		5 mg	55.00 USD
ALX-350-352-M025		25 mg	240.00 USD

Product Specification

FORMULA:	C₁₈H₁₈O₂
MW:	266.3
CAS NUMBER:	528-43-8
MERCK INDEX:	14: 5697
RTECS:	DV5105500
SOURCE/HOST:	Isolated from Magnolia officinalis.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to light yellow powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Potent and highly tolerable antitumor and antiangiogenic compound. Anxiolytic, anti-thrombotic and antibacterial. Shows central depressant effects in vivo. Inhibitor of nitric oxide (NO) and TNF-α production in LPS-activated macrophages by the suppression of inducible nitric oxide synthase (iNOS; NOS II) expression (IC₅₀=16.8µM). Isomeric with honokiol (Prod. No. ALX-350-350).

Product Specific Literature References

Pharmacological properties of Magnolol and Honokiol extracted from Magnolia officinalis: Central depressant effects: K. Watanabe, et al.; Planta Med. 49, 103 (1983) Abstract
Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine: Y. Maruyama, et al.; J. Nat. Prod. 61, 135 (1998) Abstract
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages: H.J. Son, et al.; Planta Med. 66, 469 (2000) Abstract
Inhibitory effect of magnolol on tumour metastasis in mice: K. Ikeda, et al.; Phytother. Res. 17, 933 (2003) Abstract
Magnolol-induced apoptosis is mediated via the intrinsic pathway with release of AIF from mitochondria in U937 cells: T. Ikai, et al.; Biol. Pharm. Bull. 29, 2498 (2006) Abstract; Full Text
Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors: S.J. Han, et al.; Biol. Pharm. Bull. 30, 2201 (2007) Abstract; Full Text

Related Products

ALX-350-350

Honokiol

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products for Neurological Research • Natural Products - Nitric Oxide Pathway Modulators • Anxiolytic Agents / Related Products • Antithrombotic Agents / Related Products • Natural Products with Antibiotic Activity • Natural Products - Antitumor Reagents

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