ALEXIS Biochemicals: Manoalide

ALX-350-045

Revised 07-Apr-08

Manoalide
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-045-C100		100 µg	80.00 USD
ALX-350-045-M001		1 mg	190.00 USD

Product Specification

FORMULA:	C₂₅H₃₆O₅
MW:	416.6
CAS NUMBER:	75088-80-1
SOURCE/HOST:	Isolated from Luffariella variabilis.
PURITY:	≥98% (TLC)
APPEARANCE:	Colorless oil.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Inhibits irreversibly phospholipase A₂ (PLA₂) by covalently modifying lysine residues. Also inhibits phospholipase C (PLC) and Ca²⁺ channels. Inhibits superoxide generation in polymorphonuclear leukocytes. Has anti-inflammatory and analgesic properties. Shows strong quorum sensing antagonism.

Product Specific Literature References

Manoalide, a natural sesterterpenoid that inhibits calcium channels: L.A. Wheeler, et al.; J. Biol. Chem. 262, 6531 (1987) Abstract; Full Text
Inactivation of human synovial fluid phospholipase A2 by the marine natural product, manoalide: P.B. Jacobson, et al.; Biochem. Pharmacol. 39, 1557 (1990) Abstract
Inhibition of venom phospholipases A2 by manoalide and manoalogue. Stoichiometry of incorporation: L.J. Reynolds, et al.; J. Biol. Chem. 266, 16512 (1991) Abstract; Full Text
Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia: A.M. Mayer & J.A. Spitzer; J. Pharmacol. Exp. Ther. 267, 400 (1993) Abstract
Phospholipase A2 activation in cultured mouse hepatocytes exposed to tumor necrosis factor-alpha: G.M. Adamson, et al.; J. Biochem. Toxicol. 9, 181 (1994) Abstract
Identification of two specific lysines responsible for the inhibition of phospholipase A2 by manoalide: I.D. Bianco, et al.; Biochim. Biophys. Acta 1250, 197 (1995) Abstract
Effect of manoalide on human 5-lipoxygenase activity: F. Cabre, et al.; Inflamm. Res. 45, 218 (1996) Abstract
Manoalide: A. Soriente, et al.; Curr. Med. Chem. 6, 415 (1999), Review Abstract
Quorum Sensing Antagonism from Marine Organisms: M.E. Skindersoe, et al.; Mar. Biotechnol. (NY) 10, 56 (2008) Abstract

Further Categories Containing This Product:

PLA2 Inhibitors • Ca2+ Channels Other Products • Phospholipase C/Related Products • Bacteria Other Products • Natural Products - Anti-inflammatory Agents

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