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ALX-162-001 Revised 07-Apr-08
Mastoparan
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-162-001-M001   1 mg 50.00 USD Add To Cart
ALX-162-001-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
FORMULA: C70H131N19O15
MW: 1478.9
CAS NUMBER: 72093-21-1
SOURCE/HOST: Synthetic. Originally isolated from wasp venom.
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: POTENT NEUROTOXIN.
Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis.Stimulates phospholipase D2 PLD2 activity. Alters G-proteins in brain membranes.
Product Specific Literature References
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract
Further Categories Containing This Product:
G-proteins & GTPases Other Products • Peptides
 
 
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