ALEXIS Biochemicals: MegaAPRIL™, Soluble (mouse) (H98) (recombinant)

ALX-522-092

Revised 27-Mar-06

MegaAPRIL™, Soluble (mouse) (H98) (recombinant)
SYNONYMS	rmsMegaAPRIL™ (H98) APRIL, Soluble (mouse) (recombinant):ACRP30headless (mouse) (H98) A-Proliferation-inducing Ligand (mouse) (recombinant):ACRP30headless (mouse) (H98) TNFSF 13, Soluble (mouse) (recombinant):ACRP30headless (mouse) (H98) CD256, Soluble (mouse) (recombinant):ACRP30headless (mouse) (H98)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	APRIL

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-092-3010		3x10 µg	440.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SOURCE/HOST:	Produced in HEK 293 cells. The extracellular domain of mouse APRIL (aa 98-232) is fused at the N-terminus to a mouse ACPR30headless (aa 18-110) and a FLAG^®-tag.
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	≤0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:	Binds to human and mouse BCMA and TACI. Does not bind to proteoglycans.
BIOLOGICAL ACTIVITY:	Stimulates B cell proliferation.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Information

BACKGROUND/TECHNICAL INFORMATION	FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth: M. Hahne, et al.; J. Exp. Med. 188, 1185 (1998) Abstract
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI: S.A. Marsters, et al.; Curr. Biol. 10, 785 (2000) Abstract
A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth: P. Rennert, et al.; J. Exp. Med. 192, 1677 (2000) Abstract
Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS: Y. Wu, et al.; J. Biol. Chem. 275, 35478 (2000) Abstract; Full Text
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity: G. Yu, et al.; Nat. Immunol. 1, 252 (2000) Abstract
Identification of proteoglycans as the APRIL-specific binding partners: K. Ingold, et al.; J. Exp. Med. 201, 1375 (2005) Abstract

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins

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