ALEXIS Biochemicals: Menadione

ALX-460-007

Revised 02-Feb-07

Menadione
SYNONYMS	Vitamin K₃ 2-Methyl-1,4-naphthoquinone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Vitamins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-007-G010		10 g	10.00 USD

Product Specification

FORMULA:	C₁₁H₈O₂
MW:	172.2
CAS NUMBER:	58-27-5
MERCK INDEX:	14: 5831
RTECS:	QL9100000
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow crystals.
SOLUBILITY:	Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL.

Product Description

Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.

Product Specific Literature References

Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase: F.Y. Wu and T.P.; Eur. J. Cancer 35, 1388 (1999) Abstract
Apoptosis-inducing activity of vitamin C and vitamin K: H. Sakagami, et al.; Cell Mol. Biol. 46, 129 (2000) Abstract
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells: L.K. Sun, et al.; J. Neurooncol. 47, 31 (2000) Abstract
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines: H. Okayasu, et al.; Anticancer Res. 21, 2387 (2001) Abstract
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade: L.O. Klotz, et al.; Cancer Res. 62, 4922 (2002) Abstract; Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy: J. Mauzeroll, et al.; PNAS 101, 17582 (2004) Abstract; Full Text
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells: D.N. Criddle, et al.; J. Biol. Chem. 281, 40485 (2006) Abstract; Full Text

Further Categories Containing This Product:

Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • Cell Stress, Oxidative Stress & Redox Signalling Other Products

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