ALEXIS Biochemicals: Metformin

ALX-270-432

Revised 23-May-08

Metformin
SYNONYMS	1,1-Dimethylbiguanide . hydrochloride
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Antidiabetic Agents / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-432-G001		1 g	15.00 USD
ALX-270-432-G005		5 g	20.00 USD

Product Specification

FORMULA:	C₄H₁₁N₅ . HCl
MW:	129.2 . 36.5
CAS NUMBER:	1115-70-4
MERCK INDEX:	14: 5938
RTECS:	DU1800000
PURITY:	≥97% (Assay)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:	Hygroscopic.
HAZARD:	IRRITANT.

Product Description

Antidiabetic agent. Reduces the cardiovascular complications of diabetes. Does not induce hypoglycemia.

Product Specific Literature References

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group: Lancet 352, 854 (1998) Abstract
Starting patients with type 2 diabetes on insulin therapy using once-daily injections of biphasic insulin aspart 70/30, biphasic human insulin 70/30, or NPH insulin in combination with metformin: C. Kilo, et al.; J. Diabetes Complications 17, 307 (2003) Abstract
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review: A. Natali and E. Ferrannini; Diabetologia 49, 434 (2006) Abstract
Insulin-lowering agents inhibit synthesis of testosterone in ovaries of DHEA-induced PCOS rats: T. Misugi, et al.; Gynecol. Obstet. Invest. 61, 208 (2006) Abstract

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