ALEXIS Biochemicals: Methylarachidonyl fluorophosphonate

ALX-340-017

Revised 11-Jul-08

Methylarachidonyl fluorophosphonate
SYNONYMS	MAFP Methylphosphonofluoridic acid 5,8,11,14-eicosatetraenyl ester
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	PLA2 Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-017-M001		1 mg	33.00 USD
ALX-340-017-M005		5 mg	147.00 USD

Product Specification

FORMULA:	C₂₁H₃₆FO₂P
MW:	370.5
CONCENTRATION:	10mg/ml
PURITY:	≥98%
FORMULATION:	Liquid. Solution in methyl acetate.
SOLUBILITY:	3mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 0.5mg/ml soluble in a 1:1 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stable for at least one year after receipt when stored at -80°C. We do not recommend storing aqueous solutions for more than one day.

Product Description

Selective, active-site directed, irreversible inhibitor of cPLA₂ and iPLA_2.Potent inhibitor of fatty acid amide hydrolase (FAAH) (IC₅₀=2.5nM), 800 -fold more potent than AACOCF₃ (Prod. No. ALX-340-001). Binds to the CB₁ receptor in rat brain membrane (IC₅₀=20nM).

Product Specific Literature References

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase: D.G. Deutsch, et al.; Biochem. Pharmacol. 53, 255 (1997) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.

Further Categories Containing This Product:

Cannabinoid Receptor Agonists & Antagonists / Related Products • Fatty Acid Amide Hydrolase [FAAH] / Related Products

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