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ALX-610-003 Revised 20-Jun-08
Methylene blue . trihydrate
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SYNONYMS 3,7-bis(Dimethylamino)phenothiazin-5-ium chloride . 3H2O
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Nitric Oxide & NOS Detection / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-610-003-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C16H18ClN3S . 3H2O
MW: 319.9 . 54.1
CAS NUMBER: 7220-79-3
MERCK INDEX: 14: 6060
RTECS: SP5740000
APPEARANCE: Green crystalline powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL. POTENT NEUROTOXIN.

Product Description
Inhibitor of soluble guanylyl cyclase (sGC). Biological staining agent. Spin-trap which forms stable adducts with oxygen free radicals in solution.
Product Specific Literature References
Novel actions of methylene blue: B. Mayer, et al.; Eur. Heart J 14 Suppl I, 22 (1993) Abstract
Inhibition of nitric oxide synthesis by methylene blue: B. Mayer, et al.; Biochem. Pharmacol. 45, 367 (1993) Abstract
Modulation of nitric oxide-dependent relaxation of pig tracheal smooth muscle by inhibitors of guanylyl cyclase and calcium activated potassium channels: M.S. Kannan & D.E. Johnson; Life Sci. 56, 2229 (1995) Abstract
Methylene blue induces cytotoxicity in human brain tumor cells: Y.S. Lee & R.D. Wurster; Cancer Lett. 88, 141 (1995) Abstract
Methylene blue is a muscarinic antagonist in cardiac myocytes: N. Abi-Gerges, et al.; Mol. Pharmacol. 52, 482 (1997) Abstract
A comparative study of the effects of three guanylyl cyclase inhibitors on the L-type Ca2+ and muscarinic K+ currents in frog cardiac myocytes: N. Abi-Gerges, et al.; Br. J. Pharmacol 121, 1369 (1997) Abstract
Methylene blue inhibits stimulatory effect of sodium nitroprusside but not of 3-morpholino sydnonimine on prolactin secretion in freely moving male rats: M.C. González & E. Llorente; Brain Res. Bull. 46, 229 (1998) Abstract
Comparison between endothelial and neuronal nitric oxide pathways in rat aorta and gastric fundus: C. Guilmard, et al.; Nitric Oxide 2, 147 (1998) Abstract
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea: T.L. Hwang, et al.; Br. J. Pharmacol 125, 1158 (1998) Abstract
Methylene Blue--a therapeutic dye for all seasons?: M. Wainwright & K.B. Crossley; J. Chemother. 14, 431 (2002), (Review) Abstract
Methylene blue photoinactivation of RNA viruses: R.A. Floyd, et al.; Antiviral Res. 61, 141 (2004), (Review) Abstract
Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways: H. Atamna, et al.; FASEB J. 22, 703 (2008) Abstract
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products • Neurotoxins • Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Spin Traps, Spin Probes & Spin Labels
 
 
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