ALEXIS Biochemicals: Microcystin-LA

ALX-350-096

Revised 11-Jan-08

Microcystin-LA
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Microcystins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-096-C025		25 µg	140.00 USD
ALX-350-096-C100		100 µg	210.00 USD

Product Specification

FORMULA:	C₄₆H₆₇N₇O₁₂
MW:	910.0
CAS NUMBER:	96180-79-9
RTECS:	GT2805000
SOURCE/HOST:	Isolated from Microcystis aeruginosa.
PURITY:	≥95% (HPLC)
APPEARANCE:	Whitish film adhered to inside of the vial.
SOLUBILITY:	Soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.
HANDLING:	For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD:	MAY BE CARCINOGENIC. VERY TOXIC. HIGHLY IRRITANT.

Product Description

Analog of microcystin-LR (Prod. No. ALX-350-012) with Ala substituted in place of Arg. Inhibits protein phosphatase 2A (PP2A) and protein phosphatase 3 (PP3) more potently than protein phosphatase 1 (PP1). Ozonation of toxic water samples does lead to a complete loss of the microcystins and their toxicity.

Product Specific Literature References

The structure of cyanoginosin-LA, a cyclic heptapeptide toxin from the cyanobacterium Microcystis aeruginosa: D.P. Botes et al.; J. Chem. Soc. 1, 2311 (1984)
Microcystin composition of an axenic clonal strain of Microcystis viridis and Microcystis viridis - containing waterblooms in Japanese freshwaters: K. Kaya and M.M. Watanabe; J. App. Phycol. 2007, 173 (1990)
The design, synthesis, and biological evaluation of analogues of the serine-threonine protein phosphatase 1 and 2A selective inhibitor microcystin LA: rational modifications imparting PP1 selectivity: J.B. Aggen, et al.; Bioorg. Med. Chem. 7, 543 (1999) Abstract
Treatment options for microcystin toxins: similarities and differences between variants: G. Newcombe, et al.; Environ. Technol. 24, 299 (2003) Abstract
Decrease in toxicity of microcystins LA and LR in drinking water by ozonation: S. Brooke, et al.; Toxicon. 48, 1054 (2006) Abstract

ALX-350-043	Microcystin-RR
ALX-804-585	Monoclonal Antibody to Microcystins (Adda specific) (AD4G2)
ALX-350-044	Microcystin-YR
ALX-850-319	Microcystins (Adda specific) ELISA Kit
ALX-350-148	Microcystin-LY
ALX-350-012	Microcystin-LR
ALX-350-080	Microcystin-LW
ALX-350-081	Microcystin-LF