ALEXIS Biochemicals: Microcystin-RR

ALX-350-043

Revised 06-Jun-08

Microcystin-RR
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Microcystins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-043-C050		50 µg	70.00 USD
ALX-350-043-C100		100 µg	125.00 USD
ALX-350-043-C250		250 µg	240.00 USD
ALX-350-043-C500		500 µg	470.00 USD
ALX-350-043-M001		1 mg	850.00 USD

Product Specification

FORMULA:	C₄₉H₇₅N₁₃O₁₂
MW:	1038.2
CAS NUMBER:	111755-37-4
SOURCE/HOST:	Isolated from Microcystis aeruginosa.
PURITY:	≥95% (HPLC)
APPEARANCE:	Clear to whitish film adhered to inside of vial.
SOLUBILITY:	Soluble in 80% aqueous methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD:	MAY BE CARCINOGENIC. VERY TOXIC. HIGHLY IRRITANT.
IDENTITY:	Identity determined by MS.

Product Description

Arg-Arg analog of microcystin-LR (Prod. No. ALX-350-012). Hepatotoxic, although found to be up to 10-fold less toxic than microcystin-LR on i.p. injection in mice. Potent inhibitor of protein phosphatase 2A (PP2A).

Product Specific Literature References

The structure of a cyclic peptide toxin, cyanogenosin-RR from Microcystis aeruginosa: P. Painuly, et al.; THL 29, 11 (1988)
Toxicity and toxins of natural blooms and isolated strains of Microcystis spp. (Cyanobacteria) and improved procedure for purification of cultures: M. Shirai, et al.; Appl. Environ. Microbiol. 57, 1241 (1991) Abstract
Inhibition of protein phosphatases activates glucose-6-phosphatase in isolated rat hepatocytes: S. Claeyssens, et al.; FEBS Lett. 315, 7 (1993) Abstract
Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters: L.A. Lawton, et al.; Analyst 119, 1525 (1994) Abstract
Determination of some physicochemical parameters of microcystins (cyanobacterial toxins) and trace level analysis in environmental samples using liquid chromatography: C. Rivasseau, et al.; J. Chromatogr. A 799, 155 (1998) Abstract
Physiological and biochemical analyses of microcystin-RR toxicity to the cyanobacterium Synechococcus elongatus: Z.Q. Hu, et al.; Environ. Toxicol. 19, 571 (2004) Abstract
Microcystin-RR-induced accumulation of reactive oxygen species and alteration of antioxidant systems in tobacco BY-2 cells: L. Yin, et al.; Toxicon. 46, 507 (2005) Abstract

ALX-350-044	Microcystin-YR
ALX-804-585	Monoclonal Antibody to Microcystins (Adda specific) (AD4G2)
ALX-350-148	Microcystin-LY
ALX-850-319	Microcystins (Adda specific) ELISA Kit
ALX-350-080	Microcystin-LW
ALX-350-012	Microcystin-LR
ALX-350-081	Microcystin-LF
ALX-350-096	Microcystin-LA