ALEXIS Biochemicals: Milrinone

ALX-270-083

Revised 05-Oct-06

Milrinone
SYNONYMS	1,6-Dihydro-2-methyl-6-oxo-3,4'-bipyridine-5-carbonitrile
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Phosphodiesterases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-083-M005		5 mg	85.00 USD

Product Specification

FORMULA:	C₁₂H₉N₃O
MW:	211.2
CAS NUMBER:	78415-72-2
MERCK INDEX:	14: 6197
PURITY:	≥97%
APPEARANCE:	Light red solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Selective inhibitor of phosphodiesterase 3 (PDE3).

Product Specific Literature References

Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs: S.A. Harrison, et al.; Mol. Pharmacol. 29, 506 (1986) Abstract
Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta: H.S. Ahn, et al.; Biochem. Pharmacol. 38, 3331 (1989) Abstract
Effects of isozyme-selective phosphodiesterase inhibitors on rat aorta and human platelets: smooth muscle tone, platelet aggregation and cAMP levels: S.H. Lindgren, et al.; Acta Physiol. Scand. 140, 209 (1990) Abstract
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue: J.B. Moore, Jr., et al.; Biochem. Pharmacol. 42, 679 (1991) Abstract
In vitro pharmacology of R 80122, a novel phosphodiesterase inhibitor: D. Wilhelm, et al.; J. Cardiovasc. Pharmacol. 20, 705 (1992) Abstract
Pharmacokinetics of intravenous milrinone in patients undergoing cardiac surgery: J.M. Bailey, et al.; Anesthesiology 81, 616 (1994) Abstract

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