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ALX-380-109 Revised 01-Jul-08
Minocycline . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-109-M050   50 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C23H27N3O7 . HCl
MW: 457.5 . 36.5
CAS NUMBER: 13614-98-7
MERCK INDEX: 14: 6202
RTECS: QI7630500
SOURCE/HOST: Semi-synthetic
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in water (50mg/ml, warm) or DMSO (7mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Tetracycline derivative with antimicrobial activity. Inhibitor of angiogenesis, apoptosis and poly(ADP-ribose) polymerase-1 (PARP-1). Anti-inflammatory and neuroprotective.
Product Specific Literature References
Local delivery of minocycline and systemic BCNU have synergistic activity in the treatment of intracranial glioma: J.L. Frazier, et al.; J. Neurooncol. 64, 203 (2003) Abstract
Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases: J.S. Yao, et al.; Circ. Res. 95, 364 (2004) Abstract
Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria: J. Wang, et al.; J. Biol. Chem. 279, 19948 (2004) Abstract
Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis: M. Castanares, et al.; BBRC 337, 663 (2005) Abstract
Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy: J.K. Krady, et al.; Diabetes 54, 1559 (2005) Abstract
Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations: C.C. Alano, et al.; PNAS 103, 9685 (2006) Abstract
Multiple neuroprotective mechanisms of minocycline in autoimmune CNS inflammation: K. Maier, et al.; Neurobiol. Dis. 25, 514 (2007) Abstract
Comparison of doxycycline and minocycline in the inhibition of VEGF-induced smooth muscle cell migration: J.S. Yao, et al.; Neurochem. Int. 50, 524 (2007) Abstract
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia: Y. Levkovitz, et al.; Brain Res. 1154, 154 (2007) Abstract
 
 

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