ALEXIS Biochemicals: Mithramycin A

ALX-380-097

Revised 23-Apr-08

Mithramycin A
SYNONYMS	Mithracin Aureolic acid Aurelic acid Plicamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antitumor Reagents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-097-M001		1 mg	30.00 USD
ALX-380-097-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₅₂H₇₆O₂₄
MW:	1085.2
CAS NUMBER:	18378-89-7
MERCK INDEX:	14: 7536
RTECS:	PZ2800000
SOURCE/HOST:	Isolated from Streptomyces argillaceus.
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Antineoplastic and immunosuppressive antibiotic. Inhibits transcription and protein synthesis. Substrate of P-glycoprotein (Pgp) in multidrug resistant (MDR) cancer cells. Binds to DNA in native chromatin. DNA-binding fluorescent dye.

Product Specific Literature References

Aureolic acid group of anti-tumour antibiotics: Y.U. Berlin, et al.; Nature 218, 193 (1968) Abstract
Chromomycin A3, mithramycin, and olivomycin: antitumor antibiotics of related structure: M. Slavik & S.K. Carter; Adv. Pharmacol. Chemother. 12, 1 (1975) Abstract
Mithramycin blocks protein binding and function of the SV40 early promoter: R. Ray, et al.; J. Clin. Invest. 83, 2003 (1989) Abstract; Full Text
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3: M.A. Mir, et al.; Bioorg. Med. Chem. 11, 2791 (2003) Abstract
Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression: S.Y. Ahn, et al.; Am. J. Pathol. 164, 1663 (2004) Abstract; Full Text
Mithramycin A activates Fas death pathway in leukemic cell lines: I. Leroy, et al.; Apoptosis 11, 113 (2006) Abstract

Further Categories Containing This Product:

DNA Fragmentation & Chromatin Condensation • MDR Inhibitors • Antibiotics - Immunomodulators

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