ALEXIS Biochemicals: Mitoxantrone . dihydrochloride

ALX-400-050

Revised 07-Apr-08

Mitoxantrone . dihydrochloride
SYNONYMS	1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione . dihydrochloride
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (DNA Interaction & Gene Regulation)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-050-M010		10 mg	25.00 USD
ALX-400-050-M050		50 mg	80.00 USD

Product Specification

FORMULA:	C₂₂H₂₈N₄O₆. 2HCl
MW:	444.5 . 73.0
CAS NUMBER:	70476-82-3
MERCK INDEX:	14: 6217
RTECS:	CB5748500
SOURCE/HOST:	Synthetic.
PURITY:	≥97%
APPEARANCE:	Blue to black crystalline solid.
SOLUBILITY:	Soluble in water; slightly soluble in 100% ethanol or methanol; insoluble in acetonitrile or acetone.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.

Product Description

Antiviral, antibacterial, antiprotozoal, immunomodulating, and antineoplastic cytostatic anthraquinone derivative. Induces DNA damage by intercalating into DNA and inhibiting topoisomerase II. Induces interstrand DNA cross-links and DNA-protein cross-links in cellular systems. Has recently been shown to be an inhibitor of DNA methylation.

Product Specific Literature References

Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer: D. Faulds, et al.; Drugs 41, 400 (1991) Abstract
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells: A. Skladanowski & J. Konopa; Br. J. Cancer 82, 1300 (2000) Abstract
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002) Abstract; Full Text
A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al.; J. Biol. Chem. 279, 18814 (2004) Abstract; Full Text

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