ALEXIS Biochemicals: MnTBAP chloride

ALX-430-069

Revised 25-Jan-08

MnTBAP chloride
SYNONYMS	Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Porphyrins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-069-M010		10 mg	20.00 USD
ALX-430-069-M050		50 mg	60.00 USD

Product Specification

FORMULA:	C₄₈H₂₈MnN₄O₈Cl
MW:	879.2
PURITY:	≥97%
APPEARANCE:	Black crystalline powder.
SOLUBILITY:	Dissolve at 0.1M in aqueous base, then buffer to pH 7.0 or higher as needed.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture.

Product Description

Cell permeable SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO).

Product Specific Literature References

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994) Abstract; Full Text
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275, 1227 (1995) Abstract
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996) Abstract
Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation: P. Ghafourifar, et al.; J. Biol. Chem. 274, 31185 (1999) Abstract; Full Text
Reactive oxygen species regulate activation-induced T cell apoptosis:: D.A. Hildeman, et al.; Immunity 10, 735 (1999) Abstract
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000) Abstract; Full Text
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000) Abstract; Full Text
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis: H. Dussmann, et al.; J. Biol. Chem. 278, 12645 (2003) Abstract; Full Text

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Superoxide Dismutases [SODs] / Related Products

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