ALEXIS Biochemicals: Molsidomine

ALX-430-003

Revised 13-Dec-06

Molsidomine
SYNONYMS	N-(Ethoxycarbonyl)-3-(4-morpholinyl)sydnoneimine Morsidomine SIN-10
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Donors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-003-M050		50 mg	10.00 USD
ALX-430-003-M250		250 mg	25.00 USD

Product Specification

FORMULA:	C₉H₁₄N₄O₄
MW:	242.2
CAS NUMBER:	25717-80-0
MERCK INDEX:	14: 6234
PURITY:	≥98%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Long acting antianginal drug that is enzymatically converted in the liver to yield the active metabolite SIN-1 (Prod. No. ALX-430-002).

Product Specific Literature References

H.U. Daeniker & J. Druey; Helv. Chim. Acta 45, 2426 (1962)
Molsidomine: alternative approaches to treat myocardial ischemia: R.-E. Nitz & V.B. Fiedler; Pharmacotherapy 7, 28 (1987) Abstract
Intrarenal administration of molsidomine, a molecule releasing nitric oxide, reduces renal ischemia-reperfusion injury in rats: A. Rodriguez-Pena, et al.; Am. J. Transplant. 4, 1605 (2004) Abstract
Molsidomine, a nitric oxide donor and L-arginine protects against rhabdomyolysis-induced myoglobinuric acute renal failure: V. Chander & K. Chopra; Biochim. Biophys. Acta 1723, 208 (2005) Abstract
Long-term treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina: C. Van Hove, et al.; Atherosclerosis 180, 399 (2005) Abstract
Nitric oxide donor molsidomine attenuates psychotomimetic effects of the NMDA receptor antagonist MK-801: N. Pitsikas, et al.; J. Neurosci. Res. 84, 299 (2006) Abstract

ALX-400-009	SIN-1A/γCD Complex
ALX-430-002	SIN-1 chloride