ALEXIS Biochemicals: Monactin

ALX-380-214

Revised 20-Feb-08

Monactin
SYNONYMS	Antibiotic AKD 1B 5-Demethyl-5-ethylnonactin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Immunomodulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-214-M001		1 mg	370.00 USD

Product Specification

FORMULA:	C₄₁H₆₆O₁₂
MW:	751.0
CAS NUMBER:	7182-54-9
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5448.
PURITY:	≥95% (HPLC)
APPEARANCE:	Colorless film.
SOLUBILITY:	Soluble in ethyl acetate or DMSO, moderately soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Cation ionophore with high selectivity for ammonium and potassium. Inhibits T cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ.

Product Specific Literature References

The in vitro activity of nonactin and its homologs: monactin, dinactin and trinactin: E. Meyers, et al.; J. Antibiot. (Tokyo) 18, 128 (1965) Abstract
Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin: S.N. Graven, et al.; Biochemistry 5, 1735 (1966) Abstract
On the mechanism of sugar and amino acid interaction in intestinal transport: H. Murer, et al.; J. Biol. Chem. 250, 7392 (1975) Abstract
Effects of cyclosporin A and dinactin on T-cell proliferation, interleukin-5 production, and murine pulmonary inflammation: S.P. Umland, et al.; Am. J. Respir. Cell. Mol. Biol. 20, 481 (1999) Abstract; Full Text

ALX-380-238	Trinactin
ALX-450-008	Nonactin
ALX-380-226	Dinactin