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ALX-430-094 Revised 04-Jul-07
Monastrol
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SYNONYMS 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Cycle Blockers & Inhibitors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-094-M001   1 mg 60.00 USD Add To Cart
ALX-430-094-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C14H16N2O3S
MW: 292.4
CAS NUMBER: 329689-23-8
PURITY: ≥95%
APPEARANCE: White to light yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
Product Specific Literature References
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen: T.U. Mayer, et al.; Science 286, 971 (1999) Abstract
A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC: K. Lewandowski, et al.; J. Comb. Chem. 1, 105 (1999) Abstract
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5: Z. Maliga, et al.; Chem. Biol. 9, 989 (2002) Abstract
Inhibition of a mitotic motor protein: where, how, and conformational consequences: Y. Yan, et al.; J. Mol. Biol. 335, 547 (2004) Abstract
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures: S.Y. Yoon, et al.; Cell Motil. Cytoskeleton 60, 181 (2005) Abstract
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein: T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 372, 291 (2006) Abstract
A pathway of structural changes produced by monastrol binding to Eg5: Z. Maliga, et al.; J. Biol. Chem. 281, 7977 (2006) Abstract
Allosteric inhibition of kinesin-5 modulates its processive directional motility: B.H. Kwok, et al.; Nat. Chem. Biol. 2, 480 (2006) Abstract
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products
 
 
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