ALEXIS Biochemicals: Monoclonal Antibody to Acidic Nuclear Phosphoprotein 32A (human) (RJ1)

ALX-804-811

Revised 06-Jun-06

Monoclonal Antibody to Acidic Nuclear Phosphoprotein 32A (human) (RJ1)
SYNONYMS	anti-HLA-DR-associated Protein 1 (human) MAb (RJ1) anti-PHAPI (human) MAb (RJ1) anti-Acidic Nuclear Phosphoprotein pp32 (human) MAb (RJ1) anti-PP2A Inhibitor Protein 1α (human) MAb (RJ1) anti-I₁α^PP2A(human) MAb (RJ1) anti-LANP (human) MAb (RJ1) anti-ANP32A (human) MAb (RJ1)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Protein Serine / Threonine Phosphatases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-811-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	RJ1
ISOTYPE:	Mouse IgG1
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	>95% (SDS-PAGE)
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human acidic nuclear phosphoprotein 32A.
SPECIFICITY:	Recognizes human acidic nuclear phosphoprotein 32A.
APPLICATION:	Immunocytochemistry (1:100-1:200; works on endogenous) Immunoprecipitation (works on endogenous) Western Blot (1:4'000; works on endogenous)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001) Abstract; Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002) Abstract; Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003) Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003) Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005) Abstract

General Information

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Monoclonal Antibodies

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