ALEXIS Biochemicals: Monoclonal Antibody to BAG-3 (AC-1)

ALX-803-323

Revised 27-May-08

Monoclonal Antibody to BAG-3 (AC-1)
SYNONYMS	anti-Bcl-2-binding Athanogene-3 MAb (AC-1) anti-Docking Protein CAIR-1 MAb (AC-1)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Bcl-2 Family Interacting Proteins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-323-C100		100 µg	280.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
CLONE:	AC-1
ISOTYPE:	Mouse IgG1
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 18-33 (D¹⁸RDPLPPGWEIKIDPQ³³) of N-terminal human BAG-3 (Bcl-2-binding athanogene 3).
SPECIFICITY:	Recognizes human, mouse and rat BAG-3.
APPLICATION:	ELISA Immunocytochemistry Immunohistochemistry Immunoprecipitation Western Blot
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

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Product Specific Literature References

Bag3 gene expression is regulated by heat shock factor 1: S. Franceschelli, et al.; J. Cell Physiol. 215, 575 (2008) Abstract

General Information

BAG (Bcl-2-associated athanogene) family proteins contain a BAG domain and interact with a variety of partners including heat shock proteins, steroid hormone receptors, Bcl-2 and Raf-1. BAG-1 and BAG-3 participate in a wide variety of cellular processes including signalling, transcription, stress response, and apoptosis. BAG-3 (CAIR-1; Bis) forms a complex with HSC70 and assists in polypeptide folding. In addition, this complex can mediate protein delivery to proteasome and is able to downregulate apoptosis by interfering with cytochrome c release, apoptosome assembly and other events. In human cancer cell lines, BAG-3 expression sustains cell survival and underlies resistance to therapy through downmodulation of apoptosis.

General Literature References

BAG3 protein controls B-chronic lymphocytic leukaemia cell apoptosis: M.F. Romano, et al.; Cell Death Differ. 10, 383 (2003) Abstract; Full Text
Apoptosis inhibition in cancer cells: a novel molecular pathway that involves BAG3 protein: A. Rosati, et al.; Int. J. Biochem. Cell Biol. 39, 1337 (2007) Abstract

Further Categories Containing This Product:

Co-Chaperones & HSP-interacting Proteins / Related Products • Monoclonal Antibodies

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