ALEXIS Biochemicals: Monoclonal Antibody to CD40 (mouse) (FGK45)

ALX-805-046

Revised 21-Feb-07

Monoclonal Antibody to CD40 (mouse) (FGK45)
SYNONYMS	anti-TNFRSF 5 (mouse) MAb (FGK45)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	CD40 & CD40L [CD154] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-046B-C050	Biotin	50 µg	150.00 USD
ALX-805-046-C100		100 µg	165.00 USD
ALX-805-046-C500		500 µg	440.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	FGK45
ISOTYPE:	Rat IgG2a
CONCENTRATION:	FGK45: 1mg/ml FGK45-Biotin: 0.5mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In sterile PBS.
IMMUNOGEN:	Recombinant mouse CD40 fusion protein.
SPECIFICITY:	Recognizes mouse CD40.
APPLICATION:	Flow Cytometry Functional Application (activates B and NK cells in vivo and in vitro)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
USE/STABILITY:	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep Biotin-conjugated formats at +4°C. Do not freeze. Protect from light.

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Product Description

Widely used stimulatory MAb to CD40 [1,2]. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects [3]. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes [4].

Product Specific Literature References

[1] The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching: A. Rolink, et al.; Immunity 5, 319 (1996) Abstract
[2] Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity: A.G. Rolink, et al.; Eur. J. Immunol. 28, 3738 (1998) Abstract
[3] Anti-CD40 antibody induces antitumor and antimetastatic effects: the role of NK cells: J.G. Turner, et al.; J. Immunol. 166, 89 (2001) Abstract
[4] Therapeutic activity of agonistic monoclonal antibodies against CD40 in a chronic autoimmune inflammatory process: C. Mauri, et al.; Nat. Med. 6, 673 (2000) Abstract
Click here for a complete literature overview:
[40] Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system: A. Erlebacher, et al.; J. Clin. Invest. 114, 39 (2004) Abstract; Full Text
[41] CD154 is a negative regulator of autoaggressive CD8+ T cells in type 1 diabetes: C.M. McGregor, et al.; PNAS 101, 9345 (2004) Abstract; Full Text
[42] IRF-7 is the master regulator of type-I interferon-dependent immune responses: K. Honda, et al.; Nature 434, 772 (2005) Abstract
[43] In vivo and in vitro regulation of type I IFN synthesis by synergistic effects of CD40 and type II IFN: J.A. Greene, et al.; J. Immunol. 176, 5995 (2006) Abstract
[44] IL-10- and IL-12-independent down-regulation of allergic sensitization by stimulation of CD40 signaling: P.W. Hellings, et al.; J. Immunol. 177, 5138 (2006) Abstract
[45] Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007) Abstract

Further Categories Containing This Product:

CD Antibodies • Monoclonal Antibodies

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