ALEXIS Biochemicals: Monoclonal Antibody to CD51 (human) (L230)

ALX-803-304

Revised 01-Jul-08

Monoclonal Antibody to CD51 (human) (L230)
SYNONYMS	anti-αV Integrin (human) MAb (L230) anti-Vitronectin Receptor (α Subunit) (human) MAb (L230)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	CD Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-304-C100		100 µg	240.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	L230
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.2mg/ml
PURITY:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL:	Protein A-affinity purified.
IMMUNOGEN:	Human endothelial cells.
SPECIFICITY:	Recognizes human CD51 (αV integrin). Recognizes heterodimers αVβ3, αVβ1, αVβ5 and αVβ6. Does not cross-react with other species.
APPLICATION:	ELISA Flow Cytometry Immunohistochemistry (frozen section, paraffin sections) Immunoprecipitation Note: Does not work in Western Blot.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Product Specific Literature References

A novel beta 1 integrin-dependent mechanism of leukocyte adherence to apoptotic cells: B.R. Schwartz, et al.; J. Immunol. 162, 4842 (1999) Abstract; Full Text
Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines: L. Moro, et al.; J. Biol. Chem. 277, 9405 (2002) Abstract; Full Text
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading: P. Di Stefano, et al.; Mol. Biol. Cell 15, 787 (2004) Abstract; Full Text
Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9: C.H. Williams, et al.; J. Virol. 78, 6967 (2004) Abstract; Full Text

General Information

CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.

Further Categories Containing This Product:

Monoclonal Antibodies • Angiogenesis Other Products • Bone Metabolism Other Products • Adhesion Molecules & Receptors Antibodies

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