ALEXIS Biochemicals: Monoclonal Antibody to CD59 (human) (MEM-43)

ALX-805-073

Revised 04-Jan-06

Monoclonal Antibody to CD59 (human) (MEM-43)
SYNONYMS	anti-Protectin (human) MAb (MEM-43)
PRODUCT LINE	Immunology
PRODUCT CATEGORY	CD Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-805-073-C100		100 µg	195.00 USD
ALX-805-073F-T100	FITC	100 tests	270.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	MEM-43
ISOTYPE:	Mouse IgG2a
SOURCE/HOST:	Purified from hybridoma culture supernatant by protein A affinity chromatography.
CONCENTRATION:	MEM-43: 1mg/ml
PURITY:	>95% (SDS-PAGE)
FORMULATION:	MEM-43: Liquid. In PBS, pH 7.4, containing 0.1% sodium azide. MEM-43-FITC: Liquid. In PBS, pH 7.4, containing BSA and 0.1% sodium azide.
IMMUNOGEN:	Thymocytes and T lymphocytes.
SPECIFICITY:	Recognizes a well defined epitope (W40, R-53) on human CD59 (protectin).
APPLICATION:	MEM-43: Flow Cytometry Immunoprecipitation MEM-43-FITC: Flow Cytometry (for human blood analysis use 20µl/100µl whole blood).
SHIPPING:	SHIPPED ON BLUE ICE
USE/STABILITY:	MEM-43: Short term storage at +4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles. MEM-43-FITC: Store at +4°C. Do not freeze! Protect from light!

Product Specific Literature References

Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen: V. Horejsi, et al.; Folia Biol. (Praha) 32, 12 (1986) Abstract
Gene for human CD59 (likely Ly-6 homologue) is located on the short arm of chromosome 11: U.H. Forsberg, et al.; Immunogenetics 30, 188 (1989) Abstract
Characterization of a broadly expressed human leucocyte surface antigen MEM-43 anchored in membrane through phosphatidylinositol: I. Stefanova, et al.; Mol. Immunol. 26, 153 (1989) Abstract
GPI-anchored cell-surface molecules complexed to protein tyrosine kinases: I. Stefanova, et al.; Science 254, 1016 (1991) Abstract
The nature of large noncovalent complexes containing glycosyl-phosphatidylinositol-anchored membrane glycoproteins and protein tyrosine kinases: T. Cinek & V. Horejsi; J. Immunol. 149, 2262 (1992) Abstract
CD59 molecule: a second ligand for CD2 in T cell adhesion: M. Deckert, et al.; Eur. J. Immunol. 22, 2943 (1992) Abstract
Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells: M. Cebecauer, et al.; BBRC 243, 706 (1998) Abstract
Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules: L. Cermak, et al.; J. Biol. Chem. 277, 7955 (2002) Abstract; Full Text

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Complement Regulators / Related Products • Monoclonal Antibodies

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