ALEXIS Biochemicals: Monoclonal Antibody to Caspase-11 (mouse) (8A5)

ALX-804-494

Revised 08-Jul-08

Monoclonal Antibody to Caspase-11 (mouse) (8A5)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-494-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse Rat
CLONE:	8A5
ISOTYPE:	Rat IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	p20 fragment of mouse caspase-11.
SPECIFICITY:	Recognizes mouse and rat caspase-11 (epitope in the p20 fragment). Detects two bands of ~38kDa and ~43kDa by Western blot.
APPLICATION:	Flow Cytometry, Western blot.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

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General Information

Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7. Human caspase-4, thought to be the homolog of mouse caspase-11, may be an effective therapeutic target for treatment of septic shock.

General Literature References

Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway: J. Hur, et al.; FEBS Lett. 507, 157 (2001) Abstract
Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response: S.J. Kang, et al.; Cell Death Differ. 9, 1115 (2002) Abstract
Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1: R. Schauvliege, et al.; J. Biol. Chem. 277, 41624 (2002) Abstract; Full Text

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