ALEXIS Biochemicals: Monoclonal Antibody to Caspase-12 (mouse) (12G6)

ALX-804-511

Revised 10-Mar-06

Monoclonal Antibody to Caspase-12 (mouse) (12G6)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-511-C100		100 µg	320.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	12G6
ISOTYPE:	Rat IgG1
CONCENTRATION:	1mg/ml.
FORMULATION:	Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN:	p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N¹⁸³KKFDYLFDRDNADTDILNMQEL²⁰⁵) of mouse caspase-12.
SPECIFICITY:	Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION:	ELISA Flow Cytometry Western Blot Other applications not tested.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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General Information

Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.

Further Categories Containing This Product:

Endoplasmatic Reticulum Stress • Monoclonal Antibodies

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