ALEXIS Biochemicals: Monoclonal Antibody to Caspase-14 (mouse) (70A1426)

ALX-804-228

Revised 19-Sep-05

Monoclonal Antibody to Caspase-14 (mouse) (70A1426)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-228-C100		100 µg	293.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	70A1426
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml
PURITY DETAIL:	Protein G affinity-purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Synthetic peptide corresponding to aa 2-18 of mouse caspase-14.
SPECIFICITY:	Recognizes mouse caspase-14. Detects a band of ~30kDa by Western blot.
APPLICATION:	Western Blot (2-4µg/ml)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for 6 months when stored at +4°C.

General Information

Caspase-14 (MICE for mini-ICE) is a recently member of the caspase family, related to human/mouse caspase-2 and human caspase-9. It possesses all the typical amino acid residues of the caspases involved in catalysis, including the QACRG box, and contains no or only a short prodomain. In contrast to the other short prodomain caspases (caspase-3, -6, -7), caspase-14 preferentially associates with large prodomain caspases, including caspase-1, -2, - 4, -8, and -10. Caspase-14 is not processed by multiple death stimuli including activation of members of the tumor necrosis factor receptor family and expression of proapoptotic members of the bcl-2 family.

General Literature References

Caspase-14 is a novel developmentally regulated protease: S. Hu, et al.; J. Biol. Chem. 273, 29648 (1998) Abstract; Full Text
Identification of a new caspase homologue: caspase-14: M. Van de Craen, et al.; Cell Death Differ. 5, 838 (1998) Abstract
Identification and characterization of murine caspase-14, a new member of the caspase family: M. Ahmad, et al.; Cancer Res. 58, 5201 (1998) Abstract

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Monoclonal Antibodies

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