ALEXIS Biochemicals: Monoclonal Antibody to Caspase-2 (10C6)

ALX-804-355

Revised 14-Aug-07

Monoclonal Antibody to Caspase-2 (10C6)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-355-C100		100 µg	330.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Dog Monkey
CLONE:	10C6
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human caspase-2 (p19 subunit).
SPECIFICITY:	Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2.
APPLICATION:	ELISA Flow Cytometry (1µg/ml) Immunocytochemistry (10-20µg/ml; fix in 4% paraformaldehyde, 0.18% Triton-X100 for 10 min. prior to staining) Immunohistochemistry (frozen sections)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

Product Specific Literature References

[1] Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O’Reilly, et al.; Cell Death Differ. 9, 832 (2002) Abstract; Full Text
[2] Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol. 164, 89 (2004) Abstract; Full Text
[3] Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Abstract; Full Text

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Monoclonal Antibodies

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