ALEXIS Biochemicals: Monoclonal Antibody to Caspase-2 (11B4)

ALX-804-356

Revised 05-Mar-07

Monoclonal Antibody to Caspase-2 (11B4)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-356-C100		100 µg	330.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat Dog Monkey
CLONE:	11B4
ISOTYPE:	Rat IgG2a
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human caspase-2 p19 fragment.
SPECIFICITY:	Recognizes an epitope in the p19 subunit of human, mouse, rat, monkey and dog caspase-2. Detects bands of ~51kDa (procaspase-2), ~32kDa and ~18kDa (cleavage products) by Western blot.
APPLICATION:	Immunoprecipitation Western Blot (2µg/ml) Note: For FC, ICC and IHC (FS) use MAb to Caspase-2 (10C6) (Prod. No. ALX-804-355).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

[1] Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9: L.A. O’Reilly, et al.; Cell Death Differ. 9, 832 (2002) Abstract; Full Text
[2] Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization: P. Lassus, et al.; Science 297, 1352 (2002) Abstract
[3] A novel Apaf-1-independent putative caspase-2 activation complex: S.H. Read, et al.; J. Cell Biol. 159, 739 (2002) Abstract; Full Text
[4] The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic Stress: A. Tinel & J. Tschopp; Science 304, 843 (2004) Abstract
[5] BOK and NOXA Are Essential Mediators of p53-dependent Apoptosis: A.G. Yakovlev, et al.; J. Biol. Chem. 279, 28367 (2004) Abstract; Full Text
[6] Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells: I.A. Camacho, et al.; J. Immunol. 175, 90 (2005) Abstract; Full Text

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