ALEXIS Biochemicals: Monoclonal Antibody to Cathepsin L/Procathepsin L (human) (CLP 1/36)

ALX-804-292

Revised 01-Nov-05

Monoclonal Antibody to Cathepsin L/Procathepsin L (human) (CLP 1/36)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Cathepsin Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-292-C200		200 µg	460.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	CLP 1/36
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.01% thimerosal.
IMMUNOGEN:	Synthetic peptide corresponding to aa 200-217 (Y²⁰⁰SVANDTGFVDIPKQEKA²¹⁷) of human procathepsin L.
SPECIFICITY:	Recognizes the epitope I²¹¹PKQ²¹⁴ of human procathepsin L. Recognizes mature human single or two chain cathepsin L (heavy chain) and human procathepsin L. Does not cross react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:	Immunohistochemistry (paraffin sections after microwave treatment) Western Blot Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

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Product Specific Literature References

Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth: E. Weber, et al.; J. Cancer. Res. Clin. Oncol. 120, 564 (1994) Abstract
Monoclonal antibodies against cathepsin L and procathepsin L of different species: E. Weber, et al.; Hybridoma 16, 159 (1997) Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas: P. Wurl, et al.; Virchows Arch. 430, 221 (1997) Abstract

General Information

Cathepsin L [EC 3.4.22.15] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.

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Monoclonal Antibodies

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