ALEXIS Biochemicals: Monoclonal Antibody to Clusterin (human) (CLI-9)

ALX-804-126

Revised 04-May-07

Monoclonal Antibody to Clusterin (human) (CLI-9)
SYNONYMS	anti-TRPM-2 (human) MAb (CLI-9) anti-Apolipoprotein J (human) MAb (CLI-9) anti-APO-J (human) MAb (CLI-9) anti-CLI (human) MAb (CLI-9) anti-CLU (human) MAb (CLI-9) anti-SGP-2 (human) MAb (CLI-9)
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	Clusterin/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-126-C100		100 µg	280.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	CLI-9
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Purified human clusterin (TRPM-2).
SPECIFICITY:	Recognizes human clusterin.
APPLICATION:	Immunocytochemistry Immunohistochemistry (frozen sections, paraffin sections) Immunoprecipitation Western Blot (1:2’000)
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING:	Do not freeze/thaw.

Product Specific Literature References

Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer : C. D. Hough, et al.; Cancer Res. 60, 6281 (2000) Abstract
Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent: T. Chen, et al.; Cancer Res. 64, 7412 (2004) Abstract; Full Text

General Information

Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate: J.G. Leger, et al.; BBRC 147, 196 (1987) Abstract
Apolipoprotein J: structure and tissue distribution: H.V. De Silva, et al.; Biochemistry 29, 5380 (1990) Abstract
Clusterin: the intriguing guises of a widely expressed glycoprotein: D.E. Jenne & J. Tschopp; Trends Biochem. Sci. 17, 154 (1992) Abstract
Clusterin: S.E. Jones and C. Jomary; Int. J. Biochem. Cell Biol. 34, 427 (2002), (Review) Abstract
Clusterin/Apolipoprotein J in human aging and cancer: I. Trougakos and E. Gonos; Int. J. Biochem. Cell Biol. 34, 1430 (2002) Abstract

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Monoclonal Antibodies

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