ALEXIS Biochemicals: Monoclonal Antibody to Collectrin (mouse) (2G5)

ALX-803-322

Revised 10-Apr-08

Monoclonal Antibody to Collectrin (mouse) (2G5)
SYNONYMS	anti-TMEM27 (mouse) MAb (2G5) anti-Transmembrane Protein 27 (mouse) MAb (2G5) anti-Nx17 (mouse) MAb (2G5)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Renin-Angiotensin-Aldosterone System [RAAS] Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-803-322-C050		50 µg	180.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
CLONE:	2G5
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.75mg/ml
PURITY DETAIL:	Affinity purified.
FORMULATION:	Liquid. In PBS, pH 7.2.
IMMUNOGEN:	Synthetic peptide corresponding to aa 29-46 of N-terminal mouse collectrin.
SPECIFICITY:	Recognizes mouse collectrin. Detects a band of ~44kDa.
APPLICATION:	Immunohistochemistry (paraffin sections) (1:50) Western Blot (1:500) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Essential role for collectrin in renal amino acid transport: U. Danilczyk, et al.; Nature 444, 1088 (2006) Abstract

General Information

Collectrin is a catalytically inactive homolog of angiotensin-converting enzyme 2 (ACE2). It binds to SNARE complex by interacting with snapin. Collectrin shows interesting physiological roles related to insulin seccretion, formation of primary cilia, renal cyst formation and amino acid transport. Collectrin is therefore considered as a target for various pathological processes such as diabetes, polycystic kidney disease, hypertension and aminoaciduria.

General Literature References

Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homolog of ACE2 and is developmentally regulated in embryonic kidneys: H. Zhang, et al.; J. Biol. Chem. 276, 17132 (2001) Abstract
The HNF-1alpha-SNARE connection: K. Yamagata, et al.; Diabetes Obes. Metab. 9, 40 (2007) Abstract
Collectrin, a homologue of ACE2, its transcriptional control and functional perspectives: Y. Zhang & J. Wada; BBRC 363, 1 (2007), (Review) Abstract

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Monoclonal Antibodies • Insulin & Insulin Receptor/Related Products

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