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ALX-804-245 Revised 19-May-08
Monoclonal Antibody to Cytochrome c (denatured) (7H8.2C12)
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SYNONYMS anti-Cyt c (denatured) MAb (7H8.2C12)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytochrome c
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-245-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Pig
Others
CLONE: 7H8.2C12
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity-purified.
FORMULATION: Liquid. In PBS containing 0.5% BSA and 0.05% sodium azide.
IMMUNOGEN: Non-native horse cytochrome c.
SPECIFICITY: Recognizes denatured cytochrome c from human, mouse, rat, pig, hamster, pigeon, horse, Drosophila and other species. Recognizes total cytochrome C which includes both apocytochrome c (in the cytosol without heme attached) and holocytochrome c (in the mitochondria with heme attached). Detects a band of ~15kDa by Western blot.
APPLICATION: Western Blot (1:500-1:1’000).
For immunocytochemistry, immunoprecipitation and functional application use MAb to Cytochrome c (native) (Blocking) (6H2.B4) (Prod. No. ALX-804-295).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.
Product Specific Literature References
A monoclonal antibody specific for a cytochrome c T cell stimulatory peptide inhibits T cell responses and affects the way the peptide associates with antigen-presenting cells: R. Jemmerson, et al.; Eur. J. Immunol. 21, 143 (1991) Abstract
Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells: C.J. Narvaez and J. Welsh; J. Biol. Chem. 276, 9101 (2001) Abstract; Full Text
Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL): M.A. Eid, et al.; Mol. Cancer Ther. 1, 831 (2002) Abstract
Release of intact, monomeric cytochrome c from apoptotic and necrotic cells: R. Jemmerson, et al.; Cell Death Differ. 9, 538 (2002) Abstract
Styrylpyrone Derivative (SPD) induces apoptosis in a caspase-7-dependent manner in the human breast cancer cell line MCF-7: A.T. Lee, et al.; Cancer Cel Int. 3, 16 (2003) Abstract; Full Text
Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis: C.Y. Liu, et al.; Ann. NY Acad. Sci. 1011, 133 (2004) Abstract
Mitochondria from TRAIL-resistant prostate cancer cells are capable of responding to apoptotic stimuli: Y. Liang, et al.; Cell. Signal. 17, 243 (2005 17, 243 (2005) Abstract
Further Categories Containing This Product:
Mitochondria-based Apoptosis Detection • Monoclonal Antibodies
 
 
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